Interferon production by double-stranded RNA: a comparison of induction by reovirus to that by a synthetic double-stranded polynucleotide.
نویسندگان
چکیده
منابع مشابه
Molecular Aspects of Interferon Induction by Viruses
Virus-induced interferon formation depends on the presence within the cell of a viral ribonucleic acid. This RNA may either be double stranded or, in certain cases, single stranded. The double-stranded RNA can be derived from a virus, such as reovirus, which contains this type of RNA, or it may be synthesized within the cell using viral single-stranded RNA as a template. Single-stranded RNA mus...
متن کاملThe 5'-terminal nucleotide sequences of the double-stranded RNA of human reovirus.
The 5'-terminal nucleotide sequences of human reovirus double-stranded RNA were determined after labeling the RNA with [(32)P]phosphate by polynucleotide kinase. The 5' terminal were labeled to only a limited extent prior to sequential oxidation, beta-elimination, and phosphomonoesterase treatment, indicating that the terminal phosphates were in a modified, blocked configuration. Each genome se...
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Interferon production can be stimulated by a great variety of microbial and nonmicrobial agents other than viruses. The nonmicrobial inducers can be divided into polyanions, mitogens, and a miscellaneous category including the various endotoxins and antibiotics. The polyanions appear to require a stable, high molecular weight backbone and a high density of free anionic groups whether they are p...
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Abstract Background: MicroRNAs (miRNAs) are endogenous, non-coding short RNAs (~22 nt) that can downregulate gene expression by translational repression, mRNA degradation, or transcriptional repression. miRNA misregulation has been implicated in pathogenic alterations such as cancer. In order to investigate microRNA functions in gene regulation and/or to modulate their expression in pathogenic...
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The anti-viral effect of interferon can be at least partly ascribed to an inhibitionoftranslation. The results of Kerr et al. ( I 974) and Content et al. (1975) suggested that a doublestranded RNA is a possible mediator of the effect of interferon on protein synthesis. On the other hand, interferon is known to potentiate the cytotoxic effect of doublestranded RNA (Stewart et al., 1972) and to i...
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عنوان ژورنال:
- The Journal of general virology
دوره 12 1 شماره
صفحات -
تاریخ انتشار 1971